Improvement in sodium cromoglycate delivery from a spacer device.
نویسندگان
چکیده
منابع مشابه
Improvement in sodium cromoglycate delivery from a spacer device.
The study by Dr O'Callaghan et al (June 1993;48:603-6) is an interesting attempt to study some of the variables affecting drug delivery from holding chambers. Such studies are essential if we are to use these devices optimally, and it could be argued that it is unethical to proceed to radioisotope deposition studies without such basic data. It would, however, be wrong to make general recommenda...
متن کاملImprovement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug.
BACKGROUND Aerosols generated from metered dose inhalers may be highly charged. The aim of this study was to determine whether lining the walls of a polycarbonate spacer device with an antistatic agent would result in an increase in drug output. The effects of multiple actuations of drug into the spacer device and increasing residence time of drug within the spacer were also determined. METHO...
متن کاملComparison of nedocromil sodium and sodium cromoglycate administered by pressurized aerosol, with and without a spacer device in exercise-induced asthma in children.
To compare the effectiveness of nedocromil sodium (NS) and sodium cromoglycate (SCG) administered by metered dose inhaler (MDI) in preventing exercise-induced asthma (EIA), 12 asthmatic children with EIA were studied in a randomized, double-blind, cross-over, placebo-controlled study. NS and SCG were given by MDI alone, and by MDI with a 700 ml spacer device (Fisonair, Fisons, UK), in order to ...
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The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al concludes that “there is insuYcient evidence that SCG has a beneficial eVect as maintenance treatment in children with asthma”. We do not believe this conclusion is justified. The principal criteria for assessing the eYcacy of inhaled SCG are the mean diVerences in the eVect on the symptoms ...
متن کاملSodium cromoglycate in nocturnal asthma.
To investigate whether mast cell degranulation was important in producing nocturnal asthma, the effect of a single high dose of nebulised sodium cromoglycate on overnight bronchoconstriction, oxygen saturation, and breathing patterns in eight patients with nocturnal wheeze was examined. The study took the form of a double blind placebo controlled crossover comparison. Treatment with cromoglycat...
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ژورنال
عنوان ژورنال: Thorax
سال: 1994
ISSN: 0040-6376
DOI: 10.1136/thx.49.3.289